离休的日本血吸虫雌性成虫在含肿瘤坏死因子(TNF—α) 的培养液中培养72h后,产孵量明显高于不含TNF—α的对照组.在TNF—α为 10ng/ml～40ng/ml范围内,雌虫产卵量与TNF—α呈剂量依赖性.感染血吸虫的小鼠经尾静脉反复注入多克隆抗TNF—α抗血清后,其肝脏减卵率达28.4%.结果提示TNF—α具有促进雌虫产卵的作用. Reproductive capacity of retired Schistosoma japonicum female adults cultured in culture medium containing tumor necrosis factor (TNF-α) for 72h was significantly higher than that of control group without TNF-α.In the group of TNF-α of 10ng / ml ~ 40ng / ml, the fecundity of females was dose-dependent with TNF-α.In mice infected with Schistosoma japonicum, the rate of liver ova decreased by 28.4% after repeated injection of polyclonal anti-TNF-α antiserum through tail vein.The results suggested that TNF -α has the role of promoting female eggs.