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[目的]观察扶正逐瘀中药联合内镜介入治疗急性梗阻性化脓性胆管炎(AOSC)继发全身炎症反应(SIRS)的疗效。[方法]随机选取AOSC继发SIRS的患者45例,随机分为清热解毒中药组(A组,在西医常规治疗基础上加服清热解毒中药)、扶正逐瘀中药组(B组,在A组的基础上加服扶正逐瘀中药)、及对照组(C组,仅应用西医常规治疗),每组15人,于治疗前、口服中药第3天、第7天检验血清白细胞计数(WBC)、降钙素原(PCT)、白介素6(IL-6)。[结果]A组、B组、C组中分别有1、1和2例被剔除,其余患者完成试验。口服中药第7天,检测41例患者白细胞计数:A组:(8.42±1.88)×109/L(与C组比较,差异无统计学意义);B组:(7.55±1.11)×109/L(与C组比较,差异有统计学意义);C组:(8.85±1.60)×109/L。降钙素原计数:A组:(0.83±0.39)ng/ml(与C组比较,差异无统计学意义);B组:(0.73±0.28)ng/ml(与C组比较,差异有统计学意义);C组:(1.08±0.39)ng/ml。白介素6:A组:(22.89±11.05)ng/L(与C组比较,差异无统计学意义);B组:(13.99±4.85)ng/L(与C组比较,差异有统计学意义);C组:(28.72±13.63)ng/L。[结论]清热解毒中药联合扶正逐瘀中药对AOSC继发SIRS的治疗有辅助治疗效果,可加快感染指标的恢复。
[Objective] To observe the therapeutic effect of Fuzhengzhuyu combined with endoscopic interventional therapy on acute systemic obstructive suppurative cholangitis (AOSC) secondary to systemic inflammatory response (SIRS). [Method] Forty-five patients randomly selected from AOSC secondary to SIRS were randomly divided into two groups: group A (detoxified with detoxification and traditional Chinese medicine), group B with heat and detoxifying traditional Chinese medicine (group A) (Group C), only 15 patients in each group were treated with traditional Chinese medicine. Before treatment, oral administration of traditional Chinese medicine on the third and seventh days, the serum leukocyte count (WBC) , Procalcitonin (PCT), interleukin 6 (IL-6). [Results] In group A, group B and group C, 1, 1 and 2 cases were excluded, and the remaining patients completed the test. On the 7th day after oral administration, the white blood cell count of 41 patients was examined: group A: (8.42 ± 1.88) × 109 / L (no significant difference compared with group C); group B: (7.55 ± 1.11) × 109 / L (Compared with C group, the difference was statistically significant); C group: (8.85 ± 1.60) × 109 / L. The number of procalcitonin in group A was (0.83 ± 0.39) ng / ml (compared with group C, the difference was not statistically significant); group B: (0.73 ± 0.28) ng / ml Significance); Group C: (1.08 ± 0.39) ng / ml. The level of interleukin 6 in group A was (22.89 ± 11.05) ng / L compared with that in group C (13.99 ± 4.85) ng / L in group B (the difference was statistically significant) ; C group: (28.72 ± 13.63) ng / L. [Conclusion] Qingrejiedu Chinese medicine combined with Fuzhengzhuyu Chinese medicine has the adjuvant treatment effect on the treatment of AOSC secondary SIRS, which can speed up the recovery of infection index.