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实验前24小时给去势成年雄性大鼠第三脑室注射纯化猪精液抑制素pUⅡ,结果证实抑制素在下丘脑水平有抑制GnRH释放的直接作用。pUⅡ注入第三脑室不仅阻止去势大鼠血清FSH水平的继续上升,而且也引起血清FSH含量进一步下降至注入前的水平以下。注入后3小时达到最大效应,并可持续6小时以上。此抑制效应在24小时内消失。随后,血清FSH含量与对照组一样,超过注入前水平。我们的资料提示了抑制素除了公认的直接作用于腺垂体外,还可作用于下丘脑,降低GnRH含量,选择性地抑制FSH的分泌。
The purified porcine semen inulin pUII was injected into the third ventricle of castrated adult male rats 24 hours before the experiment, and it was confirmed that inhibin had a direct effect on the inhibition of GnRH release at the hypothalamus level. Infusion of pUII into the third ventricle not only prevented the continued rise of serum FSH levels in ovariectomized rats, but also caused a further decrease in serum FSH levels below pre-infusion levels. The maximum effect is achieved within 3 hours after injection and lasts for more than 6 hours. This inhibitory effect disappears within 24 hours. Subsequently, serum FSH levels were the same as in the control group and exceeded pre-infusion levels. Our data suggest that in addition to the well-recognized direct action of inhibin in vitro on the adenohypophysis, inhibin can also act on the hypothalamus, reduce GnRH content, selectively inhibit the secretion of FSH.