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1型糖尿病是由致病性T细胞介导的免疫反应特异性攻击胰岛β细胞而导致胰岛β细胞破坏,胰岛功能进行性衰竭为特征的自身免疫性疾病。相较于2型糖尿病,1型患者由于胰岛功能差,更易合并糖尿病酮症酸中毒、严重低血糖事件等急性并发症。1型糖尿病常出现的慢性并发症主要为微血管并发症,如糖尿病视网膜病变、肾病、神经病变。此外,1型患者还常合并出现其他自身免疫性疾病,尤其是自身免疫性甲状腺疾病。下文结合2014年ADA1型糖尿病终生管理立场声明,具体分析
Type 1 diabetes is an autoimmune disease characterized by pathogenic T cell-mediated immune responses that specifically attack islet beta cells leading to the destruction of islet beta cells and progressive failure of pancreatic islet function. Compared with type 2 diabetes, type 1 patients are more likely to have acute complications such as diabetic ketoacidosis and severe hypoglycaemia due to poor islet function. Chronic complications that often occur in type 1 diabetes are mainly microvascular complications such as diabetic retinopathy, nephropathy, and neuropathy. In addition, type 1 patients are often associated with other autoimmune diseases, especially autoimmune thyroid disease. The following combination of 2014 ADA1 diabetes life-long management position statement, a specific analysis