【摘 要】
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Objective: To observe the proliferation of A-NK in vitro and antitumor activity in vivo. Methods: The growth curve of A-NK and NA-NK cells was drawn in vitro. I
【机 构】
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Institute of Oncology
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Objective: To observe the proliferation of A-NK in vitro and antitumor activity in vivo. Methods: The growth curve of A-NK and NA-NK cells was drawn in vitro. In the rat model, we compared the regional administration of A-NK-/IL-2 with the systemic administration. Results: The expansion of A-NK cells reached to climax on day 10 in the culture, increased 16.08 folds compared with the only 3.36 folds for NA-NK cells. In the rat model, we found that the regional administration of A-NK/IL-2 was better than systemic administration or administration of NA-NK/IL-2 not only in tumor infiltration and antitumor response, but also in the survival rate of rats (P＜0.05). Conclusion: A-NK cells is a new immune effecter cells with high expansibility and high antitumor activity in vivo and in vitro.
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