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吡哌酸为合成的抗菌剂,是继萘啶酸以后出现的喹诺酮类化合物,国内于1981年投产,其后开始临床应用。氟哌酸亦为化学合成抗菌剂,是萘啶酸第二代产品——氟代喹诺酮类化合物,国内已研制成功并通过鉴定。近期已投放市场。一、吡哌酸(简称PPA) (一) 药理作用口服吸收迅速而完垒,1小时可达治疗浓度,2小时达高峰,6～8小时血浓度则有下降。长效片剂6小时可达高峰浓度,维持12～24小时。本品吸收后广泛分布于各脏器、组织中,肾、肝中浓度较血内约高6～8倍,胃、肠、皮肤、肌肉等浓度均高于血液。进入人体后约70％以原形由
Pipemidic acid is a synthetic antibacterial agent, which is the quinolone compound that appears after nalidixic acid, which was put into operation in China in 1981 and then began to be used clinically. Norfloxacin is also a chemical synthesis of antibacterial agents, is the second generation of nalidixic acid products - fluoroquinolones, has been successfully developed and passed the appraisal. Recently put on the market. Pipemidic acid (PPA) (A) pharmacological effects Oral absorption rapidly and complete barrier, 1 hour up to the treatment concentration, reached the peak at 2 hours, 6 to 8 hours of blood concentration decreased. Long-lasting tablets up to 6 hours peak concentration, to maintain 12 to 24 hours. This product is widely distributed in the absorption of various organs, tissues, kidney, liver concentration of about 6 to 8 times higher than the blood, stomach, intestine, skin, muscle concentrations were higher than the blood. After entering the body about 70% of the prototype