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目的分析早、晚期透析对终末期肾病患者生存率及心血管事件发生率的影响。方法选取本院2010年5月—2013年5月收治的80例终末期肾病患者作为研究对象,按随机数字表法分为A、B两组各40例。A组接受早期透析治疗,B组则给予延迟透析治疗,两组均随访2年,比较其生存率及心血管事件发生率。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 A组随访1年、18月、2年生存率分别为100.0%、97.5%、90.0%,与B组随访生存率比较,差异均无统计学意义(均P>0.05);A组住院率为35.0%,心血管事件发生率为15.0%,腹膜炎发生率为20.0%,血管通路并发症发生率为20.0%,上述指标与B组比较,差异均无统计学意义(均P>0.05)。结论早、晚期透析治疗对终末期肾病患者生存率及心血管事件发生率的影响无明显差异,目前最佳透析时间依然较难下定论,透析时机的选择应从患者整体情况作综合分析,而不能仅依靠部分肾功能指标。
Objective To analyze the effect of early and late dialysis on the survival rate and the incidence of cardiovascular events in patients with end-stage renal disease. Methods Eighty patients with end-stage renal disease who were treated in our hospital from May 2010 to May 2013 were selected as study subjects and divided into A and B groups according to the random number table. Group A received early dialysis treatment and Group B received delayed dialysis. Both groups were followed up for 2 years and their survival rates and incidence of cardiovascular events were compared. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results The follow-up of 1-year, 18-month and 2-year survival rates in group A were 100.0%, 97.5% and 90.0% respectively. There was no significant difference between the two groups in the follow-up survival rate of group B (all P> 0.05) The incidence of cardiovascular events was 15.0%, the incidence of peritonitis was 20.0% and the incidence of vascular access complications was 20.0%. There was no significant difference between the above indexes and group B (all P> 0.05). Conclusions Early and late dialysis treatment have no significant difference on the survival rate and the incidence of cardiovascular events in patients with end-stage renal disease. The optimal dialysis time is still difficult to determine at present. The timing of dialysis should be comprehensively analyzed from the overall situation of patients, Only rely on some indicators of renal function.