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目的:分析扶正中药颗粒联合盐酸吉西他滨和顺铂(GC)化疗方案对晚期非小细胞肺癌患者的免疫功能及近期疗效的影响。方法:选择从2013年6月—2016年6月来本院就诊的118例晚期非小细胞肺癌患者为研究对象。按照随机数表法,将118例患者平均分为中药组和对照组。中药组实施扶正中药颗粒联合GC化疗方案,对照组实施单纯GC方案。3周为1个治疗周期,连续治疗2个周期后,比较两组患者治疗前后免疫功能状态、近期疗效和不良反应情况。结果:治疗前两组患者的CD_3、CD_4、CD_8和NK无统计学差异(P>0.05)。中药组患者治疗后的CD_3、CD_4、CD_8和NK相比治疗前均下降,治疗前后差异具有统计学意义(P<0.05)。治疗后,中药组的CD_3、CD_4和NK值均高于对照组,两组患者免疫功能差异显著(P<0.05)。对照组总有效率为53.45%,中药组患者的总有效率为81.66%,中药组明显高于对照组,两组患者近期疗效差异明显(P<0.05)。对照组增加稳定率仅为56.90%,中药组增加稳定率为80.00%,明显高于对照组,两组患者Karnofsky评分变化差异显著(P<0.05)。对照组总不良反应率为5.00%(3/60),两组患者不良反应情况差异明显(P<0.05)。结论:扶正中药颗粒联合GC化疗方案治疗晚期非小细胞肺癌,患者免疫功能提高,近期治疗疗效,且临床症状得到有效缓解,生活质量明显改善。
Objective: To analyze the effect of Fuzheng Granule combined with gemcitabine hydrochloride and cisplatin (GC) chemotherapy on immune function and short-term curative effect in patients with advanced non-small cell lung cancer. Methods: 118 patients with advanced non-small cell lung cancer who came to our hospital from June 2013 to June 2016 were selected as the study subjects. According to the random number table method, 118 patients were equally divided into traditional Chinese medicine group and control group. Chinese medicine group implemented Fuzheng Chinese medicine particles combined with GC chemotherapy regimen, the control group to implement a simple GC program. Three weeks for a treatment cycle, continuous treatment of two cycles, the two groups of patients before and after treatment immune function status, short-term efficacy and adverse reactions. Results: There was no significant difference in CD_3, CD_4, CD_8 and NK between the two groups before treatment (P> 0.05). After treatment, the levels of CD_3, CD_4, CD_8 and NK in Chinese medicine group decreased compared with before treatment, and the difference was statistically significant before and after treatment (P <0.05). After treatment, the levels of CD_3, CD_4 and NK in the TCM group were higher than those in the control group, with significant differences in immune function between the two groups (P <0.05). The total effective rate was 53.45% in the control group, 81.66% in the traditional Chinese medicine group, and significantly higher in the traditional Chinese medicine group than in the control group (P <0.05). The stability of the control group increased only 56.90%, the traditional Chinese medicine group increased stability was 80.00%, significantly higher than the control group, Karnofsky score difference between the two groups significantly (P <0.05). The total adverse reaction rate was 5.00% (3/60) in the control group, with significant differences in adverse reactions between the two groups (P <0.05). Conclusion: Fuzheng granule combined with GC chemotherapy in the treatment of advanced non-small cell lung cancer patients with immune function increased, the recent treatment effect, and effectively alleviate the clinical symptoms, quality of life improved significantly.