目的研究特异乳酸菌(Lb-f)对机体免疫功能的调节作用。方法采用碳粒廓清法、足跖厚度增加法和小鼠抗绵羊红细胞凝集素抗体滴度测定,分析Lb-f对KM小鼠细胞免疫及体液免疫功能的调节作用。结果 Lb-f具有呈剂量依赖性,增强小鼠单核巨噬细胞系统细胞吞噬功能;Lb-f剂量依赖性增加小鼠足跖肿差,具有提高机体细胞免疫功能的作用;Lb-f剂量依赖性提高小鼠抗绵羊红细胞凝集素抗体滴度,具有增强机体体液免疫功能的作用。结论 Lb-f可提高机体免疫功能,这可能与其治疗某些疾病存在相关性。 Objective To study the regulatory effect of Lactobacillus (Lb-f) on immune function. Methods The method of carbon clearance, increase of plantar thickness and anti-sheep anti-sheep hemagglutinin antibody titers were used to analyze the regulatory effect of Lb-f on cellular immunity and humoral immune function of KM mice. Results Lb-f had a dose-dependent manner, which enhanced phagocytosis of mouse monocyte-macrophage system. Lb-f dose-dependently increased the plantar mass in mice and increased cellular immune function. Lb-f dose Dependence increased mouse anti-sheep hemagglutinin antibody titers, with the body’s role in enhancing humoral immune function. Conclusion Lb-f can improve the body’s immune function, which may be related to the treatment of certain diseases.