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给早孕小鼠灌服马鞭草提取液,光镜观察细胞生长情况,细胞的变化及微血管分布情况。观察其对早孕小鼠子宫、胎盘、胎仔的影响,并作形态描述。实验表明:马鞭草能明显抑制胚胎生长使其固缩死亡,胚胎重量0 .129 ±0 .075 g ,与空白对照组比较有显著差异( P< 0 .05) ;胎仔长0 .32 ±0 .14 cm ,与空白对照组比较有极显著差异( P< 0 .01) ,与米非司酮组比较无显著差异( P> 0 .05) 。光镜显示:胎盘滋养层细胞退变凋亡,可见核固缩,染色质向细胞核膜下集聚。光镜下采用NYD1000 型图像分析Q 系统测定胎盘组织微血管分布面积,明显小于空白对照组( P< 0 .01) ,与米非司酮组比较无显著差异( P> 0 .05) 。结果表明马鞭草的抗早孕可能与其抗孕酮作用有关。
The mice of early pregnancy were fed with Verbena extract and observed by light microscopy for cell growth, cell changes and microvascular distribution. Observe its effect on the uterus, placenta, and fetus in early pregnancy mice and make a morphological description. Experiments showed that Verbena officinalis significantly inhibited the growth of embryos and caused the death of pyknosis. The embryo weight was 0.129±0.075 g, which was significantly different from the blank control group (P<0.05). The fetal growth was 0.32±0. At 14 cm, there was a significant difference between the control group and the control group (P < 0.01). There was no significant difference from the mifepristone group (P> 0.05). Light microscopy showed that the placental trophoblast cells degenerate and apoptosis, visible nuclear condensation, chromatin to the nuclear membrane accumulation. Under the light microscope, the NYD1000 image analysis Q system was used to determine the microvessel distribution area of the placenta, which was significantly smaller than that of the blank control group (P<0.01). There was no significant difference compared with the mifepristone group (P> 0.05). The results showed that the anti-pregnancy of Verbena officinalis may be related to its anti-progesterone effect.