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目的 :探讨分析应用脑苷肌肽注射液治疗新生儿缺氧缺血性脑病的临床疗效。方法 :选取2013年8月10日至2014年8月10日间我院收治的新生儿缺氧缺血性脑病(HIE)患儿58例作为研究对象,采用随机数字表法将其分为对照组(29例)和观察组(29例),为对照组患儿进行综合治疗,为观察组患儿在进行综合治疗的基础上加用脑苷肌肽注射液进行治疗,观察对比两组患儿神经症状的消失时间及各时间段神经行为的评分,并将对比的结果及两组患儿的临床资料进行回顾性的分析。结果 :在观察组29例患儿中,存在轻度神经症状患儿的症状消失时间为(2.41±1.01)d,存在中度神经症状患儿的症状消失时间为(7.24±0.25)d,存在重度神经症状患儿的症状消失时间为(9.67±2.53)d;在对照组29例患儿中,存在轻度神经症状患儿的症状消失时间为(4.41±1.53)d,存在中度神经症状患儿的症状消失时间为(9.31±2.23)d,存在重度神经症状患儿的症状消失时间为(10.75±2.83)d。观察组患儿的神经症状消失时间明显短于对照组患儿,差异显著(P<0.05),具有统计学意义。治疗2~3d后,观察组患儿的神经行为评分为(29.23±3.56)分,对照组患儿的神经行为评分为(29.82±3.90)分,二者之间的差异不显著(P>0.05),不具有统计学意义。治疗5~7d后,观察组患儿的神经行为评分为(35.49±2.67)分,对照组患儿的神经行为评分为(35.27±4.55)分,二者之间的差异不显著(P>0.05),不具有统计学意义。治疗10~14d后,观察组患儿的神经行为评分为(39.89±0.86)分,对照组患儿的神经行为评分为(35.88±2.21)分,观察组患儿的神经行为评分明显高于对照组患儿,差异显著(P<0.05),具有统计学意义。结论:应用脑苷肌肽注射液治疗新生儿缺氧缺血性脑病的临床疗效显著,值得在临床上推广应用。
Objective: To investigate the clinical effect of applying encephalitoside in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods: Fifty-eight neonates with neonatal hypoxic-ischemic encephalopathy (HIE) admitted to our hospital from August 10, 2013 to August 10, 2014 were selected as the research object, and were divided into control (29 cases) and observation group (29 cases). The children in the control group were treated by comprehensive treatment. The children in the observation group were treated with encephalitoside tablets on the basis of comprehensive treatment. The disappearance time of neurological symptoms and the neurological behavior scores of each time period, and the results of the comparison and clinical data of two groups were retrospectively analyzed. Results: Among the 29 children in the observation group, the symptom disappearance time in children with mild neurological symptoms was (2.41 ± 1.01) d and that in children with moderate neurological symptoms disappeared (7.24 ± 0.25) days The symptom disappearance time of children with severe neurological symptoms was (9.67 ± 2.53) days. In the control group, the symptom disappearance time was (4.41 ± 1.53) days in children with mild neurological symptoms. There were moderate neurological symptoms The symptom disappearance time in children was (9.31 ± 2.23) d, and the symptom disappearance time in children with severe neurological symptoms was (10.75 ± 2.83) d. The disappearance time of neurological symptoms in the observation group was significantly shorter than that in the control group (P <0.05), with statistical significance. After 2 to 3 days of treatment, the neurobehavioral score of the observation group was (29.23 ± 3.56) points and that of the control group was (29.82 ± 3.90) points, with no significant difference between the two groups (P> 0.05 ), Not statistically significant. The neurological behavior score of the observation group was (35.49 ± 2.67) and the neurobehavioral score of the control group was (35.27 ± 4.55) after treatment for 5-7 days, with no significant difference between the two groups (P> 0.05 ), Not statistically significant. After 10 to 14 days of treatment, the neurobehavioral score of the observation group was (39.89 ± 0.86) points, and that of the control group was (35.88 ± 2.21) points. The neurobehavioral score of the observation group was significantly higher than that of the control group Group children, the difference was significant (P <0.05), with statistical significance. Conclusion: The therapeutic effect of E-CG injection on neonatal hypoxic-ischemic encephalopathy is significant, which is worth popularizing in clinic.