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大苞雪莲总生物碱对 L_(7712)癌细胞 DNA 合成的 ID_(50)为51.7μg/ml.80μg/ml 的大苞雪莲总生物碱对 DNA、RNA 和蛋白质合成都有显著抑制作用.作用24小时,抑制率均在80%以上.对DNA 合成的抑制方式可能是模板损伤型.
The total alkaloids from the total alkaloids of Saussurea dauricus L_ (7712) on DNA synthesis of 51.7μg/ml and 80μg/ml of the total alkaloids of L. pseudoacacia have significant inhibitory effects on DNA, RNA and protein synthesis. At 24 hours, the inhibition rates were all above 80%. The inhibition of DNA synthesis may be template damage.