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自1963年Talley等开始用阿糖胞甙(简称Ara-c)治疗急性粒细胞白血病(简称急粒)以来,目前此药在治疗此类疾病中仍占重要位置。但Ara-c在人体极易发生脱氨作用而失效。最近日本发现新抗癌药环胞甙(简称Cyclo-c),对L_(1210)小鼠白血病及其他实验性肿瘤有很高的抗癌效果,现将有关Cyclo-c治疗急性白血病的临床研究综述如下。
Since Talley et al began treating acute myeloid leukemia (Arak) with Ara-c in 1963, the drug still occupies an important position in the treatment of such diseases. But Ara-c in the human body prone to deamination and failure. Recently, a new anti-cancer drug, Cyclo-c (Cyclo-c) was found in Japan, which has a high anticancer effect on L 1210 mouse leukemia and other experimental tumors. The clinical study of Cyclo-c for the treatment of acute leukemia Summarized as follows.