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目的观察急性呼吸窘迫综合征(ARDS)肠损伤中血管紧张素转换酶(ACE),乳酸脱氢酶(LDH)活性和丙二醛(MDA)含量变化,研究ARDS发病机制。方法采用尾静脉注射油酸法复制大鼠ARDS模型,测血清、肠组织匀浆ACE、LDH活性和MDA含量。结果血清、肠组织匀浆ACE,LDH活性和MDA含量均出现变化。结论血浆和组织匀浆中的ACE,LDH活性和MDA含量变化可在一定程度上反映病情的轻重,对预后有一定的提示作用。
Objective To investigate the changes of angiotensin converting enzyme (ACE), lactate dehydrogenase (LDH) activity and malondialdehyde (MDA) in the intestinal injury induced by acute respiratory distress syndrome (ARDS) and to study the pathogenesis of ARDS. Methods The rat model of ARDS was induced by tail vein injection of oleic acid, and the activities of ACE and LDH and MDA in serum and intestinal homogenate were measured. Results Serum and intestinal homogenate ACE, LDH activity and MDA content were changed. Conclusion The changes of ACE, LDH activity and MDA content in plasma and tissue homogenate may reflect the severity of illness to a certain extent, and have a certain prompting effect on prognosis.