麻醉狗的实验显示,随着异搏停血浆浓度的升高,心率呈进行性减慢.低浓度(92.2±9.6毫微克/毫升)时平均P-P间期延长11.4%,中等浓度(262.0±14.7毫微克/毫升)及高浓度(843.9±208.8毫微克/毫升)时分别延长29.6%和71.6%.6只血浓度高的狗中有2只出现窦性静止.在心房起搏时,低和中等血浆浓度均使A-H间期显著延长;所有高浓度和57.1%中等浓度的实验狗无论在 Experiments with anesthetized dogs showed a progressive slowing of heart rate with increasing plasma levels of verapamil, with an average PP interval prolongation of 11.4% at low concentrations (92.2 ± 9.6 ng / mL), moderate (262.0 ± 14.7 Ng / ml) and high concentrations (843.9 ± 208.8 ng / ml) were prolonged by 29.6% and 71.6%, respectively. Two of the six dogs with high blood concentrations had sinus arrest. In atrial pacing, both low and Moderate plasma concentrations of AH significantly prolonged interval; all high concentrations and 57.1% of the middle concentration of experimental dogs regardless of