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目的对比氨茶碱与多索茶碱治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法将120例慢性阻塞性肺疾病患者随机分为治疗组和对照组各60例。二组患者均经行抗生素静点常规治疗,其中治疗组在常规治疗基础上再给予氨茶碱治疗,对照组在常规治疗基础上加用多索茶碱治疗。观察2组患者接受治疗效果。结果治疗组总有效率为88.3%高于对照组的61.7%,不良症状消失时间为3.5d短于对照组的5.6d,差异有统计学意义(P<0.05)。治疗组症状和血气改善优于对照组,差异有统计学意义(P<0.05)。结论在治疗慢性阻塞性肺疾病方面,多索茶碱较氨茶碱具有疗效好、起效快、不良反应少等特点。即从安全和药性方面考虑,首选多索茶碱进行治疗。
Objective To compare the clinical efficacy of aminophylline and doxofylline in the treatment of chronic obstructive pulmonary disease (COPD). Methods 120 patients with chronic obstructive pulmonary disease were randomly divided into treatment group and control group of 60 cases. Two groups of patients were routine antibiotics intravenous therapy, in which the treatment group on the basis of conventional treatment and then given aminophylline, the control group on the basis of conventional treatment with doxofylline treatment. Two groups of patients were observed for therapeutic effect. Results The total effective rate was 88.3% in the treatment group and 61.7% in the control group, and the disappearance time of the adverse symptoms was 3.5 days shorter than that of the control group (5.6 days), the difference was statistically significant (P <0.05). The improvement of symptoms and blood gas in treatment group was better than that in control group, the difference was statistically significant (P <0.05). Conclusion Doxofylline is more effective than aminophylline in treating chronic obstructive pulmonary disease and has faster onset of action and fewer adverse reactions. That is, from the safety and medicinal aspects, the preferred Doxofylline for treatment.