骨的修复必需经历一系列复杂的过程。在此过程中,生长因子的序贯作用十分关键。多数骨的生长因子是由成骨细胞产生并分泌到细胞外基质中,通过自分泌和旁分泌机制影响成骨。目前已确切知道许多与骨修复有关的生长因子。其中包括骨形成蛋白(ｂｏｎｅｍｏｒｐｈｏｇｅｎｅｔｉｃｐ Bone repair must go through a series of complex processes. In the process, the sequential role of growth factors is crucial. Most bone growth factors are produced by osteoblasts and secreted into the extracellular matrix, affecting osteogenesis through autocrine and paracrine mechanisms. At present, many bone growth-related growth factors are well known. These include bone morphogenetic proteins