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目的 了解三峡库区移民幽门螺杆菌感染的血清流行病学状况。方法 通过移民流行病学病例对照方法 ,应用酶联免疫吸附试验 ,对三峡库区 16 0 0名移民与 16 0 0名非移民的幽门螺杆菌(Hp)感染状况进行研究。结果 移民区Hp感染率 (6 7.5 0 % )明显高于非移民区Hp感染率(5 3.19% ) (χ2 =13.40 ,P <0 .0 1)。婴儿期Hp感染率较高 ,儿童期开始下降 ,随年龄增加 ,又开始上升 ,与年龄呈显著正相关 (r =0 .6 2 ,P <0 .0 5 )。移民区与非移民区的Hp感染率女性高于男性 ,经统计学处理 ,差异无显著性。文化程度越低 ,Hp感染率越高 (P <0 .0 1)。一期水位淹没区移民Hp感染率明显高于二期与三期水位淹没区移民Hp感染率 (P <0 .0 1)。结论 三峡库区移民区移民Hp感染率高于非移民区居民Hp感染率 ,生活环境、文化教育程度等因素可能起着重要影响 ,库区儿童Hp感染率较高 ,对于库区移民儿童Hp感染的预防尤为重要。通过移民搬迁与移民政策的实施 ,改善经济水平与文化教育程度 ,能否降低移民Hp感染率 ,尚需进一步研究
Objective To understand the epidemiological status of Helicobacter pylori infection in the Three Gorges Reservoir area. Methods The immigrant epidemiological case-control method was used to study the status of Hp infection in 160 migrants and 160 immigrants in the Three Gorges Reservoir Area by enzyme-linked immunosorbent assay (ELISA). Results The Hp infection rate (6 7.5 0%) in immigrant areas was significantly higher than that in non-immigrant areas (5 3.19%) (χ2 = 13.40, P <0.01). Hp infection rate in infancy was higher, and childhood began to decline. With the increase of age, it started to rise again and was positively correlated with age (r = 0.62, P <0.05). Hp infection rates in immigrant and non-immigrant districts were higher than those in men, and the difference was not statistically significant. The lower the educational level, the higher the infection rate of Hp (P <0.01). The Hp infection rate of immigrants in stage I inundation area was significantly higher than that in stage II and III inundation area (P <0.01). Conclusion The Hp infection rate in Migrants resettlement area of the Three Gorges Reservoir area is higher than that of non-immigrant area residents in Hp infection rate, living environment, education level and other factors may have a significant impact on the Hp infection rate in children in the reservoir area is higher, for the reservoir area migrant children Hp infection Prevention is particularly important. Through the implementation of resettlement and relocation policies and the improvement of economic and cultural education levels, whether Hp infection can be reduced can be further studied