食管念珠菌病是免疫缺陷患者发生的主要疾病,事实上念珠菌感染是引起AIDS患者食管疾病最主要的原因.由于唑类药物比两性霉素B安全,常用于治疗AIDS患者的食管念珠菌病.在唑类药物中伊曲康唑的脂溶性最高,因而与组织结合力最强,伊曲康唑在肺、肾、脑以及表皮中的浓度数倍于血浆浓度,本文报道一种简便的高效液相色谱法测定伊曲康唑在AIDS患者血浆和食管组织中的浓度. Esophageal candidiasis is the main disease in immunodeficient patients, in fact Candida infection is the most important cause of esophageal disease in AIDS patients.As azole drugs than amphotericin B safety, commonly used in the treatment of esophageal candidiasis in AIDS patients Itraconazole in the azole drugs the highest fat-soluble, and therefore the strongest binding capacity, the concentration of itraconazole in the lung, kidney, brain and epidermis several times the plasma concentration, the paper reported a simple Determination of Itraconazole in Plasma and Esophageal Tissue of AIDS Patients by High Performance Liquid Chromatography.