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本实验采用内毒素所致家兔弥漫性血管内凝血（DIC）模型，测定外周血白介素8（IL－8）、亚硝酸根／硝酸离子（NO-2／NO-3）水平，补体C5a活性及中性粒细胞（PMN）趋化指数，并观察MEBO对上述指标的影响。结果表明：模型组血浆IL-8、NO-2／NO-3水平及C5a活性和PMN超化指数均显著升高，其升高水平和组织、器官的损害程度相一致。MEBO及地塞米松治疗组上述指标均显著降低（P＜0.01），病理组织学改变亦轻。提示：IL—8、－氧化氮（NO）参与DIC发病过程，MEBO抑制炎症反应，防止DIC的作用机理部分是通过调控细胞因子网络而实现的。
In this study, endotoxin-induced diffuse intravascular coagulation (DIC) was used to determine the levels of IL-8, NO-2 / NO-3 and C5a And neutrophil (PMN) chemotactic index, and observe the impact of MEBO on these indicators. The results showed that the level of plasma IL-8, NO-2 / NO-3, C5a activity and PMN hyperosmolality index in model group were significantly increased. The level of IL-8 and NO-2 / MEBO and dexamethasone treatment group were significantly lower indicators (P <0.01), histopathological changes are also light. It is suggested that IL-8 and NO play an important role in the pathogenesis of DIC. MEBO can inhibit the inflammatory reaction and prevent the mechanism of DIC partly through the regulation of cytokine network.