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目的:研究祁白芷根脂溶性化学成分。方法:应用溶剂法和色谱法分离纯化化合物,利用谱学技术鉴定化合物结构。结果:分离得到27个化合物,分别鉴定为异欧前胡素(1)、别异欧前胡素(2)、水合氧化前胡素(3)、比克白芷素(4)、别欧前胡素(5)、β-谷甾醇(6)、邻苯二甲酸二丁酯(7)、7-羟基-6-(3-甲基-2-丁烯氧基)-香豆素(8)、花椒毒酚(9)、5-羟基-8-甲氧基补骨脂素(10)、奥氏芹二醇(11)、伞形花内酯(12)、香柑内酯(13)、欧前胡素(14)、珊瑚菜内酯(15)、异茴芹素(16)、6-乙酰基-7-甲氧基-香豆素(17)、补骨脂素(18)、异东莨菪内酯(19)、滨蒿内酯(20)、花椒毒素(21)、当归醇A(22)、氧化前胡素乙醇醚(23)、去氢柳叶白姜花内酯(24)、尤劳帕替醇(25)、独活属醇(26)、栓翅芹烯醇(27)。结论:化合物8为新的天然产物;除化合物1,3,14外,其余化合物均为首次从祁白芷根中分离得到。
Objective: To study the fat-soluble chemical constituents of Radix Angelicae Sinensis. Methods: The compounds were isolated and purified by solvent method and chromatography. The structures of the compounds were identified by spectroscopic methods. RESULTS: Twenty-seven compounds were isolated and identified as isoimperatorin (1), isoimperatorin (2), hydromoxidin (3), picokiolide (4) (5), β-sitosterol (6), dibutyl phthalate (7), 7-hydroxy- 6- (3-methyl- 2- butenyloxy) ), Xanthohumol (9), 5-hydroxy-8-methoxypsoralen (10), parsleydiol (11), ursolide (12) , Imperatorin (14), Coraline lactone (15), Anisinogen (16), 6-Acetyl-7-methoxy- coumarin (17), Psoralen , Scopolactone (19), scoparone lactone (20), sage toxin (21), angelica alcohol A (22), oxaliplatin ether (23) Ester (24), urapidil (25), ilexol (26), and plug-wing enol (27). Conclusion: Compound 8 is a new natural product. Except for compounds 1, 3 and 14, the other compounds were isolated from the root of Angelica dahurica for the first time.