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本文对21例偏头痛患者血小板和血浆5-HT含量和血小板聚集率在发作期和间歇期的变化做了观察,结果表明:偏头痛患者血小板5-HT含量无论是发作期还是间歇期,与对照组比较均显著增高(P均<0.01);血浆5-HT含量在发作期显著低下(P<0.01),而间歇期显著增高(P<0.01);血小板和血浆5-HT比值在发作期明显增高(P<0.01),间歇期无明显变化(P>0.05)。血小板诱导聚集在发作期和间歇期与对照组比较均无明显差异(P均>0.05)。我们认为偏头痛患者血小板和血浆5-HT含量及比值异常可能与其发病机理有关。
In this paper, the changes of platelet and plasma 5-HT levels and platelet aggregation in 21 patients with migraine were observed during the episodes and intermittent periods. The results showed that the platelet 5-HT levels in patients with migraine were significantly higher than those in patients with migraine The content of 5-HT in plasma was significantly lower in the attack phase (P <0.01), while the intermittent phase was significantly higher (P <0.01). The ratio of platelet to plasma 5-HT in the attack phase (P <0.01), but there was no significant change in intermission (P> 0.05). There was no significant difference in induction of platelet aggregation at the onset and intermission compared with the control group (all P> 0.05). We believe that migraine patients with platelet and plasma 5-HT levels and abnormal ratio may be related to its pathogenesis.