Effects of Acupuncture on Expressions of the Transcription Factors NF-E2,YB-1,LRG47 in the SAMP10 Mi

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To explore the mechanism of acupuncture for delaying aging. Methods: Using the senescence accelerated mouse patt SAMP10 and the normal aging mice SAMR1 as models and applying RT-PCR and digoxin (DIG)-labeled North blot technique to observe expressions of NF-E2,YB-1,LRG47 genes in the forebrain,cortex and hippocampus in a 8-month old SAMR1 control group,a 8-month old SAMP10 control group,a 8-month old SAMP10 acupuncture group and a 8-month old SAMP10 non-point stimulation group.Results: In the SAMP 10 control group,the expressions of NF-E2,YB-1 and LRG47 were down-regulated in the forebrain,cortex and hippocampus,and after acupuncture they were up-regulated and tended to normal. Conclusion: The brain aging of the SAMP10 mice is related with abnormal expressions ofNF-E2,YB-1 and LRG47 genes; and acupuncture can regulate the expressions of NF-E2,YB-1 and LRG47 genes,strengthening the functions of erythrocyte series,increasing the proliferation of cells and enhancing the cellular immune function in anti-bacteria,hence delaying aging.
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