目的探讨急性心肌梗死(AM I)和陈旧性心肌梗死(OM I)患者血尿酸、胆红素水平的变化及意义。方法分别测定AM I组、OM I组和对照组的血尿酸、胆红素水平。结果AM I组血尿酸明显高于OM I组(P<0.05)和对照组(P<0.01),总胆红素和间接胆红素明显高于OM I组(P<0.01)和对照组(P<0.05);OM I组血尿酸明显高于对照组(P<0.05),总胆红素和间接胆红素低于对照组(P<0.05)。结论血尿酸水平升高和低胆红素与冠心病密切相关,早期干预有可能预防心血管事件的发生。 Objective To investigate the changes and significance of serum uric acid and bilirubin in patients with acute myocardial infarction (AMI) and old myocardial infarction (OMI). Methods The levels of serum uric acid and bilirubin in AM I group, OM I group and control group were determined respectively. Results Serum uric acid in AMI group was significantly higher than that in OM I group and control group (P <0.01), total bilirubin and indirect bilirubin were significantly higher than those in OM I group and control group P <0.05). Serum uric acid in OM I group was significantly higher than that in control group (P <0.05), total bilirubin and indirect bilirubin were lower than those in control group (P <0.05). Conclusion The elevated serum uric acid level and low bilirubin are closely related to coronary heart disease. Early intervention may prevent cardiovascular events.