1959～1973年美国陆军医学研究和发展部发起一项抗辐射药物发展协作计划,目的是要发现一个药物或药物复方,在核武器袭击时给军队人员或其他人群服用,使他们在电离辐射作用时得到保护。在此期间化学合成和在小鼠中试验了约4400个化合物,绝大多数是氨基硫醇类。直至1973年,为了研究新药应用制备了5个化合物,对其中三个进行了有限制的人体耐受量研究。 1959-1973 United States Army Medical Research and Development Department launched a collaborative program for the development of anti-radiation drugs aimed at identifying a drug or drug compound to be used by military personnel or other groups in the event of a nuclear weapon attack to allow them to interact with ionizing radiation Be protected. About 4400 compounds were chemically synthesized and tested in mice during this period, the vast majority being aminothiols. Until 1973, five compounds were prepared for the study of new drug applications, and three of them were studied for limited human tolerance.