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目的:探讨乳杆菌制剂定君生在治疗外阴阴道念珠菌病(VVC)中的临床效果。方法:对2005年3月～2006年5月在该院就诊的VVC患者133例分为三组,定君生组30例,定君生联合抗真菌制剂硝酸米糠唑(达克宁栓)组52例(联合组),以上两组为观察组,达克宁组51例为对照组。分别于用药前和用药后2、4、8周进行阴道分泌物检查及阴道PH值测定,观察三组疗效。结果:治疗后2周复查有效率联合组为98.08%,达克宁组为96.08%,两组差异无显著性;定君生组50.00%,明显低于前两组(P<0.05)。治疗后4周复查,复发率联合组为1.96%、达克宁组为8.16%、定君生组为6.67%,三组比较差异无显著性。治疗后8周复查,复发率联合组为10.00%、达克宁组为44.44%、定君生组为14.28%,联合组和定君生组明显低于对照组(P<0.05),联合组与定君生组比较差异无显著性。治疗后联合组和定君生组阴道乳杆菌数量均多于对照组(P<0.05),且阴道PH值低于对照组(P<0.05)。结论:单纯应用乳杆菌制剂治疗VVC近期效果不满意,但治愈者复发率低。联合应用乳杆菌制剂和抗真菌制剂治疗VVC效果满意且复发率低。
Objective: To investigate the clinical effect of Ding Jun Sheng in the treatment of vulvovaginal candidiasis (VVC). Methods: From March 2005 to May 2006, 133 patients with VVC in this hospital were divided into three groups. Thirty patients in Dingjun group and 52 in non-pregnant women with daphniazepam (Combined group), the above two groups were observation group, 51 cases of dacronine group as control group. Respectively before medication and 2, 4, 8 weeks after treatment vaginal discharge examination and vaginal pH measurement, the three groups observed efficacy. Results: The effective rate of two weeks after treatment was 98.08% in the combination group and 96.08% in the Dakening group. There was no significant difference between the two groups (P <0.05). Four weeks after treatment, the recurrence rate was 1.96% in the combination group, 8.16% in the Dacronide group and 6.67% in the Dingjun group, showing no significant difference between the three groups. 8 weeks after treatment, the recurrence rate was 10.00% in the combination group, 44.44% in the Dacronide group, and 14.28% in the Dingjun group. The combined group and Dingjun group were significantly lower than those in the control group (P <0.05) There was no significant difference between monarch group and monarch group. After treatment, the number of Lactobacillus in the combined group and Dingjun group were more than those in the control group (P <0.05), and the vaginal PH value was lower than that in the control group (P <0.05). Conclusion: Lactobacillus preparation is not satisfied with the short-term effect of VVC, but the recurrence rate of cured patients is low. The combination of Lactobacillus and antifungal agents in the treatment of VVC is satisfactory and the recurrence rate is low.