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以1-羟基-2-萘甲酸与2-甲氧基萘为起始原料通过多步反应合成了标题化合物。首先将1-羟基-2-萘甲酸转化为1-(-)-薄荷氧基-2-萘甲酸-(-)-薄荷酯,再将2-甲氧基萘转化为1-溴-2-甲氧基萘,1-溴-2-甲氧基萘的格氏试剂与酯反应得到(S)-2’-甲氧基-1,1’-联萘-2-甲酸-(-)-薄荷酯。该薄荷酯再经还原反应、氧化反应、加成反应、氧化反应得到标题化合物。对各步反应的实验条件进行了适当改进,找到了较好的合成条件,并用1HNMR和13CNMR对各步产物进行了表征。
The title compound was synthesized by a multi-step reaction using 1-hydroxy-2-naphthoic acid and 2-methoxynaphthalene as starting materials. 1-Hydroxy-2-naphthoic acid is first converted to 1 - (-) - menthoxy-2-naphthoic acid- (-) - menthyl ester and 2-methoxynaphthalene is then converted to 1- Methoxynaphthalene and 1-bromo-2-methoxynaphthalene to obtain (S) -2’-methoxy-1,1’-binaphthyl-2-carboxylic acid- Menthol. The menthyl ester is subjected to a reduction reaction, an oxidation reaction, an addition reaction and an oxidation reaction to obtain the title compound. The experimental conditions of each step were properly improved, and the better synthesis conditions were found. The products of each step were characterized by 1HNMR and 13CNMR.