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采用银染端粒重复序列扩增方法，对４６例病理诊断为良、恶性肿瘤患者的肿瘤组织及病灶周围组织进行了端粒酶活性检测。结果表明：２５例病理诊断为恶性肿瘤患者的肿瘤组织中，全部检测到端粒酶活性，阳性率为１００％；１８例恶性肿瘤患者的病灶周围组织中，１１例检测到端粒酶活性，阳性率为６１％；２１例病理诊断为良性肿瘤患者的肿瘤组织中，３例检测到端粒酶活性弱阳性。提示端粒酶活性检测对恶性肿瘤的诊断和预后判断有重要的参考价值。
The telomerase activity was detected in 46 cases of benign and malignant tumors and the tissues around the lesions using the silver-stained telomere repeat amplification method. The results showed that the telomerase activity was detected in 25 tumor tissues of 25 patients with pathologically diagnosed malignancy, and the positive rate was 100%. Telomerase activity was detected in 11 cases of 18 patients with malignant tumors. The positive rate was 61%; in the tumor tissues of 21 patients with pathological diagnosis of benign tumors, weak telomerase activity was detected in 3 cases. It is suggested that the detection of telomerase activity has important reference value for the diagnosis and prognosis of malignant tumors.