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目的 二甲基亚硝胺 (ＮＤＭＡ)和氯乙烯 (ＶＣ)这两种间接致癌物需经肝实质性细胞 (ＰＣ)活化后才具有致ＤＮＡ损伤作用。为验证经肝ＰＣ活化代谢的ＮＤＭＡ物中间活性产物能否“传递”给肝非实质性细胞 (ＮＰＣ) ,引起后者ＤＮＡ损伤。方法 应用单细胞微量凝胶电泳技术对Ｎ?
Objective The indirect carcinogens of dimethylnitrosamine (NDMA) and vinyl chloride (VC) need to be activated by liver parenchymal cells (PC) to induce DNA damage. To verify whether the intermediate active products of NDMA metabolized by liver-activated PC could “pass” to hepatic insubstantial cells (NPCs), causing DNA damage in the latter. Methods Single-cell microgel electrophoresis technique for N?