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Objective:The aim of our study was to detect the correlation between the expressions of HER2 and VEGF in breast cancer,and their relations with some pathological factors.Methods:By immunohistochemistry technique,the expressions of HER2 and VEGF in the post-operation samples of 117 cases with breast cancer were assessed,and their relations with some pathological factors were analysed by statistical methods.Fifty samples of hyperplasia of mammary glands were observed as the control.Results:The positive expression rates of HER2 and VEGF in breast cancer were both significantly higher than those in hyperplasia of mammary gland (P＜0.05).The expressions of HER2 and VEGF were both correlated to lymph node metastasis (P＜0.05),but showed no relations with age,histological type,histological stage,tumor size (P＞0.05).The positive expression rate of HER2 had a positive correlation with those of VEGF (P＜0.05,r=0.373).Conclusion:The expressions of HER2 and VEGF have no correlations with age,histological type,histological stage,tumor size,but are closely related with lymphatic metastasis.The positive expression rates of HER2 shows a positive correlation with those of VEGF.