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目的了解再次放疗对鼻咽癌复发病人的治疗价值，并试图分析可能影响再放疗结果的因素。材料与方法１９９１年１月～１９９３年１１月治疗的１１３例复发性鼻咽癌，所有的病人均接受外照射，其中５１例加腔内放疗（１９２Ｉｒ）。结果总的４年生存率、无瘤生存率、局控率分别是５１．２％、４８．３％和４９．９％。分析了复发间隔期对于生存率、局控率和无瘤生存率的关系。观察了２４例病例的初发及复发病灶的细胞凋亡发生情况，发现细胞凋亡数、分裂相数目差异无统计学意义。结论复发性鼻咽癌的再放疗仍是相当有效，尤其是对于复发间隔期大于２年的病例。但在治疗方法上可考虑采用一些非常规的治疗方法。
Objective To understand the therapeutic value of reradiation on patients with recurrent nasopharyngeal carcinoma and try to analyze the factors that may affect the outcome of reradiation. Materials and Methods From January 1991 to November 1993, 113 patients with recurrent nasopharyngeal carcinoma were treated. All patients underwent external beam irradiation, of which 51 received intracavitary irradiation (192Ir). Results The overall 4-year survival rate, tumor-free survival rate and local control rate were 51.2%, 48.3% and 49.9% respectively. The relationship of recurrence interval to survival rate, local control rate and tumor-free survival rate was analyzed. 24 cases of primary and recurrent lesions observed apoptosis, found that the number of apoptotic cells, the number of split phase was no significant difference. Conclusion Reradiation of recurrent nasopharyngeal carcinoma is still quite effective, especially for patients with recurrence interval greater than 2 years. However, in the treatment may be considered some unconventional treatment.