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研究目的探讨小儿复发性肾病综合征有效的治疗方法。研究背景目前,对小儿肾病综合征的治疗仍以强的松加环磷酰胺为主,疗效不十分理想,复发率高。为解决这一问题,我们试用了ACTH加氮芥治疗小儿肾病综合征。研究方法 54例患儿随机分为两组,观察组36例,以ACTH加氮芥治疗,对照组18例,以强的松加环磷酰胺治疗。对治疗结果进行统计学处理。结果治疗后观察组各项主要指标(水肿、蛋白尿、胆固醇和血浆白蛋白)的恢复优于对照组。观察组和对照组完全缓解率分别为94.1％和66.7％(P<0.01)。结论 ACTH加氮芥治疗小儿肾病综合征效果优于强的松加环磷酰胺。
Objective To investigate the effective treatment of children with recurrent nephrotic syndrome. Research Background At present, the treatment of children with nephrotic syndrome is still dominated by prednisone plus cyclophosphamide, the effect is not very good, high recurrence rate. To solve this problem, we tried ACTH plus nitrogen mustard treatment of children with nephrotic syndrome. Methods 54 cases of children were randomly divided into two groups, the observation group of 36 cases, ACTH plus nitrogen mustard treatment, control group of 18 patients treated with prednisone plus cyclophosphamide. The treatment results were statistically analyzed. Results After treatment, the main indicators of the observation group (edema, proteinuria, cholesterol and serum albumin) recovery was better than the control group. The complete response rate was 94.1% in the observation group and 66.7% in the control group (P <0.01). Conclusion ACTH plus nitrogen mustard treatment of children with nephrotic syndrome is better than prednisone plus cyclophosphamide.