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对19名慢性心力衰竭患者进行一项双盲交叉试验,先用单次量的甲巯丙脯酸25mg和哌唑嗪2mg;然后将上述药量分别增加到50mg和4mg,一日三次,治疗一个月。 用药后1～2小时,甲巯丙脯酸血中浓度达峰值,而哌唑嗪较慢,此二药均有类似效果,能减轻左右心室充盈压、全身血管阻力与血压;两药均能增加心功能指数。但仅有甲巯丙脯酸降低心率,甲巯丙脯酸能明显增加血浆肾素活性并使血浆醛固酮降到正常值。而哌唑嗪仅轻度增加肾素活性,能显著增加血浆去甲肾上腺素。
Nineteen patients with chronic heart failure were given a double-blind crossover trial with a single dose of 25 mg of captopril and 2 mg of prazosin, and then the above doses were increased to 50 mg and 4 mg, respectively, three times a day A month 1 to 2 hours after treatment, peak plasma concentration of captopril, and prazosin slower, the two drugs have similar effects, can reduce left ventricular filling pressure, systemic vascular resistance and blood pressure; both drugs can Increase heart function index. However, only captopril decreased heart rate, captopril increased plasma renin activity and decreased plasma aldosterone levels to normal. Prazosin only slightly increased renin activity, can significantly increase plasma norepinephrine.