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目的:探讨布拉氏酵母菌预防儿童化脓性脑膜炎长期使用抗生素后继发真菌感染的疗效。方法:将住院治疗的60例长期使用抗生素儿童化脓性脑膜炎患儿分为布拉氏酵母菌组、双歧杆菌三联活菌组及对照组,每组20例。布拉氏酵母菌组患儿自使用抗生素开始口服布拉氏酵母菌散剂(亿活),双歧杆菌三联活菌组自使用抗生素开始口服双歧杆菌三联活菌肠溶胶囊(贝飞达),对照组患儿仅使用抗生素。抗生素使用2周内观察患儿出现鹅口疮和抗生素相关性腹泻的发生率,取患儿的粪便进行真菌培养。结果:应用三代头孢菌素后6天,对照组患儿即出现口腔急性假膜型念珠菌感染,2周内口腔急性假膜型念珠菌病共9例和腹泻15例,腹泻患儿粪便白色念珠菌检出率高达60%;双歧杆菌三联活菌组患儿在应用抗生素8天后出现口腔急性假膜型念珠菌病7例和腹泻11例,腹泻患儿粪便中检出白色念珠菌6例;布拉氏酵母菌组患儿在应用抗生素12天后才出现口腔急性假膜型念珠菌病和腹泻各2例,且腹泻患儿粪便中未检出白色念珠菌。结论:对长期应用抗生素的化脓性脑膜炎患儿加用布拉氏酵母菌可有效预防继发性真菌感染。
Objective: To investigate the curative effect of B. Saccharomyces in the prevention of secondary fungal infection in children with purulent meningitis after prolonged use of antibiotics. Methods: Sixty children with long-term use of antibiotics in children with purulent meningitis were divided into three groups: B fl yeast group, Bifidobacterium triple viable group and control group, 20 cases in each group. Children with Braga yeast began oral administration of B. burgdorfer powder (100 million live) using antibiotics, and Bifidobacterium triple viable bacteria group started oral administration of Bifidobacterium triple viable enteric-coated enteric-coated capsules (antibiotics from antibiotics) Children in the control group only used antibiotics. Antibiotics 2 weeks to observe the incidence of thrush and antibiotic-related diarrhea in children with faeces in children with fungal culture. Results: Six days after the third generation cephalosporin was given, oral candidiasis was observed in the control group. In the second week, there were 9 cases of acute pseudomembranous candidiasis and 15 cases of diarrhea. Candida albicans detection rate as high as 60%; Bifidobacterium triple viable group of children in the application of antibiotics 8 days after the emergence of oral acute pseudomembranous candidiasis in 7 cases and 11 cases of diarrhea in children with Candida albicans 6 For example, 2 cases of acute pseudomembranous candidiasis and 2 cases of diarrhea occurred in children with B. Cerevisiae only after 12 days of antibiotic treatment. Candida albicans was not detected in the stool of children with diarrhea. Conclusion: The addition of S.pastoris to children with purulent meningitis long-term antibiotics can effectively prevent secondary fungal infection.