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目的对γ-羟基丁酸钠联合放疗减少放射性脑损伤及其作用机理进行探讨研究。方法采用γ-羟基丁酸钠配合常规放疗对实验动物的脑损伤进行病理学观察,以Mistra肾上腺素自氧化法、Uchiyama试验分别测定SOD活力和LPO含量。结果γ-羟丁酸钠明显减少6MeVβ射线辐照后脑组织损伤,而且可提高SOD活力及减少LPO含量。结论γ-羟丁酸钠减少放射性脑组织损伤、缓解放疗反应,在提高脑胶质瘤放射治疗效果中发挥着重要作用。
Objective To investigate the mechanism of γ-hydroxybutyrate combined with radiotherapy to reduce radiation-induced brain injury. Methods The brain injury of experimental animals was observed by γ-hydroxybutyrate and routine radiotherapy. The activity of SOD and the content of LPO were determined by Mistra adrenaline autooxidation and Uchiyama test respectively. Results Sodium gamma-hydroxybutyrate significantly reduced brain tissue injury after 6MeV beta irradiation, but also increased SOD activity and decreased LPO content. Conclusion Sodium gamma-hydroxybutyrate can reduce radioactive brain injury and relieve the radiation reaction, which plays an important role in improving the radiotherapy effect of glioma.