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采用腹腔注射交感神经化学切断剂６－羟多巴胺（６－ＯＨＤＡ）的方法，在小鼠束缚应激模型上观察外周交感神经在应激免疫抑制蛋向产生中的作用。结果表明，腹腔注射６－ＯＨＤＡ后，血清中应激免疫抑制蛋白的产生明显减少，第五天降至最低点，以后逐渐恢复，第 １４天恢复正常。脾脏和淋巴结中去甲肾上腺素（ ＮＥ）的含量，在注射６－ＯＨＤＡ后第一天明显降低，而且至少在１４天内维持在很低水平。说明６－ＯＨＤＡ已损坏了交感神经纤维。注射６－ＯＨＤＡ前３０ｍｉｎ注射去郁敏（ＤＭＩ），阻断交感神经的重吸收作用，可明显对抗６－ＯＨＤＡ抑制应激免疫抑制蛋白产生作用。以上结果表明，外周交感神经具有促进应激免疫抑制蛋白生成的作用。
The effect of peripheral sympathetic nerve on the production of stress-suppressed immunosuppressive egg was observed on mouse model of restraint stress by intraperitoneal injection of 6-hydroxydopamine (6-OHDA). The results showed that the intraperitoneal injection of 6-OHDA, serum immunosuppressive protein production significantly reduced the stress, the fifth day to the lowest point, then gradually recovered, the first 14 days returned to normal. The levels of norepinephrine (NE) in the spleen and lymph nodes were significantly reduced on the first day after injection of 6-OHDA and remained at very low levels for at least 14 days. Description 6-OHDA damaged sympathetic nerve fibers. Injection of 6-OHDA 30min before injection of dexmedetomidine (DMI), blocking the re-absorption of the sympathetic nerve, 6-OHDA can significantly antagonize the inhibition of stress immunosuppressive protein production. The above results show that peripheral sympathetic nerve can promote the production of stress immunosuppressive protein.