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脑梗死是由于脑部供血障碍,引起脑组织缺血性坏死,是神经系统常见病、多发病,致死率和致残率均高,且大部分幸存者存在不同程度的神经功能障碍。国内外大量研究认为,血浆纤维蛋白原水平增高是脑梗死发生和发展的危险因素之一[1]。Hamsten等[2]报道因纤维蛋白原基因水平的变异引起血浆纤维蛋白原水平改变占所有因素的51%,纤维蛋白原基因的多态性决定血浆纤维蛋白原的功能表达状态,基因多态
Cerebral infarction is due to brain blood supply disorders, causing ischemic necrosis of the brain is a common disease of the nervous system, frequently-occurring disease, fatality and morbidity were high, and most survivors have varying degrees of neurological dysfunction. A large number of domestic and foreign studies suggest that elevated plasma fibrinogen is one of the risk factors for the occurrence and development of cerebral infarction [1]. Hamsten et al [2] reported that changes in fibrinogen levels caused by changes in plasma fibrinogen levels accounted for 51% of all factors, fibrinogen gene polymorphism determines the functional status of plasma fibrinogen, gene polymorphism