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目的:对标题化合物Co()-牛磺酸缩-5-甲基-2-羟基-1,3-苯二甲醛席夫碱配合物[Co(C13H16N2O7S2)(H2O)3]2.H2O进行体外抗菌活性研究。方法:采用连续稀释法测定该化合物对金黄色葡萄球菌、乙型溶血性链球菌、肺炎链球菌和大肠杆菌的最低抑菌浓度。结果:该化合物在浓度为0.5325 mg/ml时,对肺炎链球菌无菌落生长,而对金黄色葡萄菌、乙型溶血性链球菌和大肠杆菌都有菌落生长。结论:该化合物对肺炎链球菌有体外抗菌活性,其MIC值为0.5325 mg/ml,而对金黄色葡萄球菌、乙型溶血性链球菌和大肠杆菌都无体外抗菌活性。
OBJECTIVE: To investigate the inhibitory effect of the title compound Co () - taurine-5-methyl-2-hydroxy-1,3-benzenedicarbohide complex [Co (C13H16N2O7S2) (H2O) 3] Antibacterial activity research. Methods: The minimum inhibitory concentration of this compound against Staphylococcus aureus, Streptococcus hemolyticus, Streptococcus pneumoniae and Escherichia coli was determined by serial dilution method. Results: The concentration of 0.5325 mg / ml of the compound on Streptococcus pneumoniae colony growth, and Staphylococcus aureus, hemolytic streptococcus and Escherichia coli have colony growth. Conclusion: The compound has antibacterial activity against Streptococcus pneumoniae in vitro and its MIC value is 0.5325 mg / ml, while it has no in vitro antibacterial activity against Staphylococcus aureus, Streptococcus hemolyticus and Escherichia coli.