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一般认为伯喹和乙胺嘧啶并用根治疟疾或抗复发可获满意效果,但亦有观察提出二者并用可致加重伯喹毒性反应。1973年1月某部新兵连504名战士在合并使用伯喹和乙胺嘧啶过程中,广东籍92名新兵中74名(80.4%)于服药2～4天内出现明显毒性反应,主要表现是头痛、头昏、乏力、厌食、恶心、呕吐、紫绀、贫血、谷丙酶升高(16例),以及溶血性黄疽(24例)等,其中16例症状较严重者送医院治疗,1例因溶血严重,
It is generally believed that both primaquine and pyrimethamine can be used to cure malaria or have an anti-relapse effect. However, it has also been observed that the combination of the two can lead to the increase of primaquine toxicity. In January 1973, a department of recruit with 504 fighters in the process of the merger of primaquine and pyrimethamine, Guangdong, 92 recruits (80.4%) showed significant toxic reactions within 2 to 4 days of taking the medication, the main manifestation of headache , Dizziness, fatigue, anorexia, nausea, vomiting, cyanosis, anemia, elevated valproate (16 cases) and hemolytic jaundice (24 cases), of which 16 cases of more serious symptoms were sent to the hospital for treatment, 1 case Due to severe hemolysis,