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目的研究三七总皂苷(PNS)肠溶微丸对动脉粥样硬化(AS)模型家兔肝细胞的影响。方法建立家兔AS模型,连续ig给予PNS原料药及不同剂量的PNS肠溶微丸,阳性药血栓通注射剂(冻干)采用肌肉注射给药。分别给予相应的药物干预后,通过测定各组兔肝脏脂肪变性的分级程度、肝系数,同时进行HE染色观察肝组织病理改变并进行结果分析,评价肝脏损伤程度和药物对AS模型家兔肝细胞的影响。结果与模型组比较,PNS肠溶微丸低剂量能明显降低肝脏脂肪变性及AS模型家兔的肝系数;PNS肠溶微丸低剂量的效果优于PNS原料药组。结论 PNS原料药及其制剂均能显著减轻肝脏脂肪变性程度及降低肝系数,且PNS肠溶微丸低剂量优于PNS原料药及血栓通注射剂(冻干)。
Objective To study the effect of PNS enteric coated pellets on hepatic cells in rabbits with atherosclerosis (AS) model. Methods Rabbit model of AS was established. PNS and PNS enteric pellets were continuously given by ig. The positive drug Xueshuantong injection (lyophilized) was injected intramuscularly. After given the corresponding drug intervention, the degree of hepatic steatosis and hepatic coefficient in each group were determined, and the pathological changes of liver tissue were observed by HE staining and the results were analyzed to evaluate the degree of hepatic injury and the effect of the drug on hepatic cells of AS model rabbits Impact. Results Compared with the model group, low doses of PNS enteric-coated pellets could significantly reduce hepatic steatosis and hepatic coefficient of AS model rabbits. The effect of low-dose PNS enteric-coated pellets was better than that of PNS group. Conclusion PNS and its preparations can significantly reduce the degree of hepatic steatosis and reduce the hepatic coefficient, and PNS enteric-coated pellets at a lower dose than the PNS API and Xueshuantong injection (freeze-dried).