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本研究对30例皮质动脉区脑梗塞(CACI)、32例穿通动脉区脑梗塞(PACI)、32例原发性高血压病患者及年龄性别与CACI患者匹配的无心脑血管病等的对照者以ELISA法测定血清Lp(α)水平。结果显示对照者与高血压病者血Lp(α)均值相近,而CACI患者血Lp(α)均值显著高于对照者,PACI患者其值虽亦高于对照者,但其中高于对照者血Lp(α)水平第95%位数值280.32mg/L者并不多于对照组;且脑梗塞患者发病2周内血Lp(α)水平相对稳定。提示高水平血Lp(α)是动脉粥样硬化(AS)性脑梗塞的危险因素,而非脑梗塞发生的致病因素。
In this study, 30 patients with cortical artery infarction (CACI), 32 patients with cerebral infarction (PACI), 32 patients with essential hypertension and age-matched CACI patients without cardiovascular and cerebrovascular disease control The level of serum Lp (α) was measured by ELISA. The results showed that the control and hypertensive patients with blood Lp (α) mean similar to CACI patients with Lp (α) mean was significantly higher than the control, PACI patients, although its value is higher than the control, but higher than the control blood Lp (α) level of 95% of the value of 280.32mg / L were not more than the control group; and cerebral infarction within 2 weeks of onset of blood Lp (α) levels were relatively stable. It is suggested that high level blood Lp (α) is a risk factor of atherosclerotic cerebral infarction, not a causative factor of cerebral infarction.