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目的分析汕头大学医学院第一附属医院2010年l月至2012年1月临床分离的肺炎链球菌对抗菌药物的耐药性,指导临床合理用药。方法回顾性分析54例肺炎链球菌性疾病(PDs)患者的临床资料及54株肺炎链球菌菌株的药敏试验结果。结果 50岁以上、2岁以下的患者占总数的83.3%(45/54)。儿童侵袭性PDs占侵袭性PDs患者的80.0%(8/10)。肺炎链球菌对红霉素、克林霉素及复方新诺明均有相当高的耐药率,对万古霉素、左旋氧氟沙星100%敏感。侵袭性PDs分离株与非侵袭性PDs分离株的耐药性分析结果有很多相似之处。结论应该积极对50岁以上的中老年人、2岁以下儿童接种肺炎链球菌疫苗;万古霉素、左旋氧氟沙星对该菌敏感性较高。
Objective To analyze the drug resistance of S. pneumoniae isolates from January 2010 to January 2012 in the First Affiliated Hospital of Medical College of Shantou University and to guide clinical rational drug use. Methods The clinical data of 54 patients with pneumococcal disease (PDs) and the susceptibility test results of 54 strains of Streptococcus pneumoniae were retrospectively analyzed. Results The patients over 50 years old and under 2 years old accounted for 83.3% (45/54) of the total. Children’s aggressive PDs accounted for 80.0% (8/10) of patients with aggressive PDs. Streptococcus pneumoniae to erythromycin, clindamycin and cotrimoxazole have a very high rate of resistance to vancomycin, levofloxacin 100% sensitive. There are many similarities in drug resistance analysis results between invasive PDs isolates and noninvasive PDs isolates. Conclusion Streptococcus pneumoniae vaccines should be actively administered to the middle-aged and elderly people over 50 years old and children under 2 years old. Vancomycin and levofloxacin are highly susceptible to this bacterium.