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目的探讨胃癌组织微血管密度(MVD)和血管内皮生长因子(VEGF)表达与临床病理间的关系。方法对27例胃癌组织标本行常规石蜡包埋及5μm切片,然后行MVD及VEGF免疫组化染色。结果MVD平均值为37．81±10．99(个/视野),VEGF阳性率为59．26％。VEGF阳性组中的MVD值明显高于VEGF阴性组。MVD、VEGF表达与肿瘤TNM分期及有无淋巴结转移有统计学意义相关性(P＜0．05),与组织学分化程度及浆膜层是否受侵无统计学显著性意义(P＞0．05)。结论胃癌MVD值和VEGF表达密切相关,在胃癌发生、发展和转移中起重要作用,两者均可作为反映胃癌生物学行为的有用指标。
Objective To investigate the relationship between the microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) and the clinicopathological features in gastric cancer. Methods Twenty-seven gastric cancer specimens were routinely paraffin-embedded and 5μm sections. MVD and VEGF immunohistochemical staining were performed. Results The average MVD was 37.81 ± 10.99 (a / field), the positive rate of VEGF was 59.26%. The MVD in VEGF-positive group was significantly higher than that in VEGF-negative group. The correlation between the expression of MVD and VEGF and TNM staging and lymph node metastasis (P <0.05) was not statistically different from that of histological differentiation and invasion of serosa (P> 0.05). 05). Conclusions The MVD value of gastric cancer is closely related to the expression of VEGF and plays an important role in the occurrence, development and metastasis of gastric cancer, both of which may be used as a useful indicator to reflect the biological behavior of gastric cancer.