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目的对传统的纯钛帽改良后植入兔颅骨,建立新的种植体表面处理研究的动物模型。方法运用数控机床对纯钛板进行机械加工,压制中空半球形钛帽,底部添加自攻性螺纹,顶部添加两个环形小孔。48个纯钛帽植入12只新西兰兔颅骨。选取观察时间点为2周、4周,6周。通过大体标本和牙科微型CT观察纯钛帽植入的稳定性,制作带金属不脱钙硬组织切片,观察纯钛帽植入兔颅骨的动物实验模型骨组织效应。结果手术过程中植入共48个纯钛帽,其中2个松动,松动率为4.17%;植入2、4、6周取材时,48个标本无松动,脱落。牙科微型CT结果显示,纯钛帽能够稳定在兔颅骨上。带金属不脱钙硬组织切片显示,新旧骨组织形成明显界限,周围骨组织长入纯钛帽底部的螺纹,嵌合良好。结论改良自攻性纯钛帽制作加工相对传统的钛帽工艺简单,稳定性良好,减少辅助固定装置,减少手术创伤,简化操作步骤,提高实验效率,可以用于研究种植体表面处理方式的动物模型。
Objective To improve the traditional titanium cap implanted rabbit skull, the establishment of a new implant surface treatment animal model. Methods The pure titanium plate was machined by using a CNC machine, a hollow hemispherical titanium cap was pressed, a self-tapping thread was added at the bottom, and two annular small holes were added at the top. Forty-eight titanium caps were implanted into 12 New Zealand rabbit skulls. Select the observation time points for 2 weeks, 4 weeks, 6 weeks. The stability of titanium cap implantation was observed by gross specimen and dental micro-CT, the non-decalcified hard tissue with metal was made and the bone tissue effect was observed in the experimental model of the implanted rabbit skull. Results During the operation, a total of 48 titanium caps were implanted. Two of them were loosened and the rate of loosening was 4.17%. When the samples were taken at 2, 4, and 6 weeks after implantation, 48 specimens did not loosen or fall off. Dental micro-CT results show that the titanium cap can be stabilized on the rabbit skull. With metal non-decalcified hard tissue sections showed that the old bone formation of a clear boundary, the surrounding bone tissue into the titanium cap at the bottom of the thread, good fitting. Conclusion Improved self-tapping titanium cap manufacturing Titanium cap relative to the traditional process of simple, good stability, reduce the auxiliary fixation device to reduce surgical trauma, simplify the operation steps and improve the efficiency of experiments can be used to study the implant surface treatment of animals model.