【摘 要】
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Macroautophagy (hereafter referred to as autophagy) is a conserved eukaryotic process,in which dysfunctional pro-teins,organelles,and other macromole-cules are wrapped in intracellular vesicles called autophagosomes and de-livered to lysosomes for degrada
【机 构】
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Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function,Department of Bi
论文部分内容阅读
Macroautophagy (hereafter referred to as autophagy) is a conserved eukaryotic process,in which dysfunctional pro-teins,organelles,and other macromole-cules are wrapped in intracellular vesicles called autophagosomes and de-livered to lysosomes for degradation(Mizushima et al.,2008;Mizushima and Komatsu,2011).Autophagy restores cel-lular energy and recycles cytoplasmic precursors,sustaining cell homeostasis and cell survival (Mizushima et al.,2008;Mizushima and Komatsu,2011).Elevated autophagy can be detected in both cancer cells and surrounding stro-mal cells in pancreatic cancer (PC),af-fecting tumor initiation and progression as well (Yang et al.,2011;Endo et al.,2017).The role of autophagy in PC is highly context-dependent.Here,we illus-trate the multifactorial role of autophagy in PC,and the significance of autophagy will be emphasized not only in cancer cells but also in the tumor microenvironment.
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