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细胞因子是由免疫细胞和某些非免疫细胞经刺激而合成分泌的一类具有广泛生物学活性的小分子蛋白,它在机体正常和异常的生命活动过程中均具有重要而复杂的生物学作用,它们之间通过合成和分泌的相互调节,受体表达的相互调节、生物学效应的相互影响等组成一个复杂的细胞因子网络。免疫性血小板减少性紫癜(ITP)是一种以血小板减少和皮肤粘膜出血为特征的自身免疫性疾病,研究表明细胞因子水平的异常导致的细胞因子网络失衡在ITP发病中具有重要作用。细胞因子疗法已被用于自身免疫性疾病,随着细胞因子网络与ITP研究的不断深入和基因工程技术、细胞分子生物技术的日趋成熟,细胞因子疗法将成为治疗ITP的有效措施。
Cytokines are a class of small, biologically active small molecule proteins that are secreted by immune cells and certain non-immune cells and have important and complex biological roles in the normal and abnormal life processes of the body , They constitute a complex network of cytokines through the mutual regulation of synthesis and secretion, mutual regulation of receptor expression and biological effects. Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by thrombocytopenia and mucocutaneous hemorrhage. Studies have shown that cytokine network imbalance caused by abnormal cytokine levels plays an important role in the pathogenesis of ITP. Cytokine therapy has been used in autoimmune diseases. With the development of cytokine network and ITP, genetic engineering and the maturation of cellular and molecular technologies, cytokine therapy will be an effective treatment for ITP.