Three Novel Eremophilanolides from Ligularia virgaurea spp.oligocephala

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From the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala,three novel eremophilane sesquiterpene lactones, 6α, 10α-dihydroxy-l-oxoeremophila-7(11),8(9)-dien-8, 12-olide, 6β, 10α-dihydroxy-1-oxoeremophila-7 (11), 8 (9)-dien-8, 12-olide and 10α-hydroxy-l-oxoeremophila-7(11), 8(9)-dien-8, 12-olide were isolated. Their structures were elucidated by various spectroscopic methods including intensive 2D NMR techniques (COSY,HMQC, HMBC and 1H- 1H NOESY) and HR-MS.
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