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目的:探讨盐酸戊乙奎醚在急性乌头碱中毒致心律失常患者抢救中的地位。方法:60例急性乌头碱中毒致心律失常患者在催吐、洗胃、导泻等对症支持治疗基础上使用盐酸戊乙奎醚1～4 mg肌内注射,发生心室颤动者给予非同步电除颤,复律后仍出现室性心动过速给予利多卡因静脉注射,观察治疗效果。结果:60例患者(轻度中毒54例,重度中毒6例)全部治愈出院,治愈率为100%,4例患者出现一过性烦躁、亢奋,其余均未出现明显不良反应。轻度中毒患者盐酸戊乙奎醚用量仅1 mg,重度中毒患者盐酸戊乙奎醚用量不超过4 mg。结论:催吐、洗胃、导泻等对症支持治疗基础上早期及时使用盐酸戊乙奎醚,必要时加用利多卡因等可提高乌头碱中毒致心律失常患者抢救成功率。
Objective: To investigate the status of penehyclidine hydrochloride in the rescue of patients with arrhythmia caused by acute aconitine poisoning. Methods: Sixty acute aconitine-induced arrhythmias patients were given intramuscular injection of penehyclidine hydrochloride 1 ~ 4 mg on the basis of symptomatic supportive therapy such as emetic, gastric lavage and cathartic cats. Tremor, after cardioversion still appears ventricular tachycardia intravenous lidocaine to observe the therapeutic effect. Results: 60 patients (mild poisoning in 54 cases, severe poisoning in 6 cases) were cured and discharged, the cure rate was 100%, 4 patients had transient irritability, excited, and the rest were no obvious adverse reactions. Mild poisoning patients penehyclidine hydrochloride dosage is only 1 mg, severe poisoning patients penehyclidine hydrochloride dosage does not exceed 4 mg. Conclusion: The early and timely use of penehyclidine hydrochloride on the basis of symptomatic supportive therapy such as vomiting, gastric lavage and catharsis, and the use of lidocaine when necessary can improve the rescue success rate of patients with arrhythmia caused by aconitine poisoning.