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目的 研究胃癌切除前后 T细胞亚群数量和功能两方面的变化 ,并就其变化与术后感染的关系进行探讨。方法 分别用3H- Td R渗入法和单个核细胞直接免疫荧光法检测 38例胃癌患者 Ts功能和 T细胞亚群水平 ,并对手术切除后不同时间点进行了对比。结果 胃癌患者无论手术前后 Ts功能明显高于正常人 (P<0 .0 1) ,而其本身在肿瘤切除前后差异无显著意义 (P>0 .0 5 ) ;胃癌术前 CD4 / CD8明显降低 (P<0 .0 0 1) ;术后 CD4 先降后升 ,CD8则轻度增高 ,CD4 / CD8在术后 9～ 12 d恢复到术前水平 ;术后 2～ 3d,CD4 下降的感染率为 4 3.5 % ,CD4 增高的感染率为 13.3%。结论 胃癌患者的细胞免疫功能明显低下 ,手术切除肿瘤有利于其功能的恢复 ,但同时手术创伤亦可引起一定程度的免疫抑制 ,且与术后感染有关
Objective To study the changes of the number and function of T cell subsets before and after resection of gastric cancer, and to explore the relationship between the changes and the postoperative infection. Methods Ts function and T lymphocyte subsets of 38 patients with gastric cancer were detected by 3H-TdR infiltration and direct immunofluorescence assay of mononuclear cells, and compared at different time points after surgical resection. Results Before and after operation, the function of Ts in gastric cancer patients was significantly higher than that in normal people (P <0.01), but there was no significant difference between before and after resection (P> 0.05). The preoperative CD4 / CD8 of gastric cancer was significantly lower (P <0.01). CD4 decreased first and then increased, while CD8 increased slightly. CD4 / CD8 returned to the preoperative level 9-12 days after operation. Rate of 3.55%, CD4 infection rate was 13.3%. Conclusion The cellular immune function of patients with gastric cancer is obviously low. Surgical resection of the tumor is conducive to the recovery of its function, but at the same time surgical trauma can also cause some degree of immunosuppression and is associated with postoperative infection