磺脲类口服药是治疗2型糖尿病的主要药物,临床应用非常广泛,但其继发失效的发生率每年为5%~10%,连续5年后可达40%~50%〔1〕。目前认为主要原因有β细胞分泌胰岛素功能进一步衰竭、外周组织胰岛素抵抗加重、磺脲类药物慢性脱敏、肝糖输出增加及周围组织糖利用减少等。本次研究采 Sulfonylurea oral drug is the treatment of type 2 diabetes, the main drug, clinical application is very wide, but the incidence of secondary failure every year for 5% to 10%, 5 consecutive years up to 40% to 50% [1]. At present, the main reason is the further failure of β-cell function of insulin secretion, increased peripheral insulin resistance, sulfonylurea chronic desensitization, increased hepatic glucose output and the surrounding tissue to reduce the use of sugar. This study mining